Espheres EM

ESPHERES EM (Microcrystalline Cellulose Spheres)

MCC (Micro Crystalline Cellulose) spheres are hard free flowing spherical masses prepared principally using MCC and Espheres EM are available containing 100% MCC also.

The ingredients used are having GRAS status and are compliant to monographs of all the recognized pharmacopoeias.

Important Features of Espheres EM

  • Uniform sphere size
  • Low friability
  • Insoluble in water
  • Uniform and consistent loading
  • Cost effective
  • Availability in a wide size range

General Physico-chemical Characteristics

Appearance White to off white hard free flowing spherical pellets
Loss on Drying Not more than 7% w/w
pH 5 to 7.5 (2% aqueous dispersion)
Solubility Insoluble in water
Microbial Enumeration Test Complies with pharmacopoeial requirements
Pathogens Absent

Storage conditions

Protect from excessive temperature moisture and freezing.

Re-evaluation Date - 36 months from the date of manufacture.


These spheres can be used as an inert base for modified release formulations promoting consistency and uniformity of release profile thus ensuring a uniform therapeutic response.

Particle Sizes (U.S. Standard Sieve) Available

#20 – #30, #30 – #40 and #40 – #60

  • Other intermediate sizes can be considered on request.
  • Size considerations - Not less than 90% pass through the coarser sieve size and not more than 10% passes the finer sieve. These sizes are stated on the label.

For more details about ESPHERES™ products, please contact us at