Instacoat EN Super II

Product Description

INSTACOATTM EN-SUPER-II is a fully formulated enteric coating system based on Methacrylic Acid Copolymer Type C. It is a patented product for aqueous reconstitution. It is recommended in the cases where phthalate esters such as CAP or HPMCP are not compatible or pose stability problems. Typically, a weight gain in the range 8 -12 % is sufficient to achieve reliable enteric protection.

Features Benefits


  • Dry powder system for reconstitution
  • Process time savings from rapid coating suspension manufacture
  • Complete coating formulation minus solvent
  • Cost savings in inventory and inventory management
  • Advanced colour control methods
  • Reproducible finished product appearance
  • Avoidance of customer complaints
  • White or ready coloured systems matched to your specification or sample are available. Anti-counterfeiting and branding features can be built-in
  • Meeting diverse marketing requirements is facilitated
  • Colours used are checked for compliance with appropriate regulations in target markets
  • Avoidance of regulatory issues


  • Methacrylic Acid copolymers are the most widely used and accepted enteric polymers worldwide
  • Absence of regulatory problems and delays
  • Development and production staff are familiar with process requirements
  • Easy scale-up and production introduction
  • Aqueous processing
  • Safer working environment
  • Environmentally friendly
  • Low viscosity coating system
  • Low atomisation pressure required
  • Excellent tablet-to-tablet coating uniformity
  • Smooth & glossy appearance
  • Rapid dispersibility in water
  • Rapid suspension preparation
  • Glidant is included
  • Overcomes polymer tack issues and contributes to productivity gains
  • Can be applied in a wide range of equipment designs and sizes from most manufacturers
  • Easy scale-up and transfer to different equipment types or manufacturing sites.
  • Suitable for batch and continuous processes.

Regulatory information

All products are checked for the regulatory compliance of all ingredients in the target countries and market segments of sale. This determination is made at the time the initial formulation is established, based on customer-supplied information. If market countries and/or segments are extended once the formulation has been established, customers are encouraged to contact us to ensure that regulatory compliance is not compromised.

INSTACOATTM EN SUPER-II is a fully formulated enteric coating system based on Methacrylic Acid Copolymer Type C. It is a patented product for aqueous use. It is recommended in the cases where phthalate esters such as CAP or HPMCP are not compatible or pose other problems. Typically, a weight gain of around 9% provides reproducible delayed release profiles.

Recommended Solvent System and Reconstitution Level

  • Purified water at up to 20% w/w solids

Equipment / Accessories

  • Variable-speed mechanical stirrer (do not use high-shear equipment)
  • Mixing Vessel

Calculation of Instacoat EN SUPER-II and solvent quantities

  • Determine the quantities of Instacoat EN SUPER-II (20% w/w solids) and water required based on the quantity of tablets to be coated and the target coating weight gain. e.g.: For coating 1.0 kg of tablets to 8% wt. gain, weigh 88 g Instacoat and 352 gm purified water at room temperature (includes 10% overage for losses).

Reconstitution Process

  • Add the weighed quantity of water to a mixing vessel.
  • Using a mechanical stirrer, stir the purified water to form a vortex.
  • Add the required quantity of Instacoat EN SUPER-II to the centre of the liquid vortex in a slow steady stream, avoiding clumping while maintaining a vortex and completing powder dispersion within 5 minutes. Once this has been achieved, reduce the stirrer speed to eliminate the vortex and continue mixing for 45 minutes.

Recommended Process Conditions

(fully perforated) pans
(non perforated) pans
Pan diameter (inch) 24-60 12-36
Tablet load (kg) 10-300 0.5-50
Weight gain (%) 8-9 %
Number of guns 1-6 1-2
Liquid nozzle diameter (mm) 1.0-1.5
Atomising air pressure (bar) 1.5-2.5
Pattern air pressure To achieve maximum uniform bed coverage
Tablet bed temperature (⁰C) 30-35
Inlet air temperature (⁰C) Set to achieve required product bed temperature
Suspension spray rate Set to achieve required product bed temperature
Exhaust air volume To maintain slight negative pressure in pan
Pan speed Minimum for steady tablet flow through spray zone

*Tablet bed temperature offers the most effective way of controlling the coating process. Where this measurement is unavailable, exhaust temperature may be substituted. However, the relationship between the two measurements is complex and depends on several factors such as pan load, pan depression, pan design and airflow rate. Indicated exhaust temperature may be above or below the true bed temperature. It is recommended that the relationship between the two measurements is calibrated.

Typical Constituents

Methacrylic Acid Copolymer Type C; Plasticiser; Titanium Dioxide; Edible Pigments; Alkaliser; Glidant.